Assessing Toxicity of Fine and Nanoparticles: Comparing In Vitro Measurements to In Vivo Pulmonary Toxicity Profiles

Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles.

Previous studies have reported little correlation between the relative toxicity of particle types when comparing lung toxicity rankings following in vivo instillation versus in vitro cell culture exposures. This study was designed to assess the capacity of in vitro screening studies to predict in vivo pulmonary toxicity of several fine or nanoscale particle types in rats. In the in vivo compone...

In Vitro and In Vivo Toxicity Studies of Engineered Nanoparticles

Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles.

Oxide Nanoparticles Morteza Mahmoudi,* Heinrich Hofmann, Barbara Rothen-Rutishauser, and Alke Petri-Fink* Laboratory of Powder Technology, Ecole Polytechnique F ed erale de Lausanne, Lausanne, Switzerland (http://ltp.epfl.ch) National Cell Bank, Pasteur Institute of Iran, Tehran, Iran (www.biospion.com) Institute for Nanoscience and Nanotechnology Research Center, Faculty of Pharmacy, Tehran Un...

In vivo Toxicity Investigation of Magnesium Oxide Nanoparticles in Rat for Environmental and Biomedical Applications

Background: Magnesium oxide nanoparticles are characterized with a wide variety of applications and are mass-produced throughout the world. However, questions remain regarding their safety. There has been paucity of toxicology research on their side effects, especially under in vivo conditions. Objectives: The present paper aims at evaluating the...

In Vivo Toxicity Assessment of Bovine Serum Albumin and Dimercaptosuccinic Acid Coated Fe3O4 Nanoparticles

Background: Recently, applications of nanoparticles in many fields of medicine have been developed, due to their specific physical and chemical properties. Therefore assessment of their toxicity specially in the in vivo condition is necessary. Objectives: The aim of this study is to evaluation the effect of Fe3O4 nanoparticles coating by biocompatible compounds on their t...